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Immune reactions towards a person’s own body are often associated with severe pathology and ongoing destruction of the affected tissue. The standard treatment with immune suppressants aims to impede this chronic process but can in turn permanently damage the body. For many of those affected, homeopathy offers a possible solution to this dilemma. This issue of SPECTRUM examines questions such as what needs to be considered when treating autoimmune disease with homeopathy and how to coordinate this with conventional treatment, which methodological approaches are relevant and also which remedy groups are particularly well-suited as well as how to assess the reaction. The healing processes seen in the numerous cases presented – including vitiligo, rheumatoid arthritis, ankylosing spondylitis and chronic inflammatory bowel disease – demonstrate the potential of homeopathic treatment for autoimmune problems. Our renowned international authors from a range of homeopathic schools present their approach to this clinical problem with its severe pathology.